食品科学 ›› 2020, Vol. 41 ›› Issue (15): 295-300.doi: 10.7506/spkx1002-6630-20200301-001

• 专题论述 • 上一篇    下一篇

miRNA与电离辐射防护功能食品研究进展

鲁吉珂,陈培,曹娜娜,陈晨,伊娟娟,郝利民   

  1. (1.郑州大学生命科学学院,河南 郑州 450001;2.军事科学院军需工程技术研究所,北京 100010)
  • 出版日期:2020-08-15 发布日期:2020-08-19
  • 基金资助:
    国家自然科学基金青年科学基金项目(31201342);河南省自然科学基金面上项目(162300410305); 军队科研项目(BEP20C006;BX115C007);河南省高等学校青年骨干教师培养计划项目(2017GGJS0090)

Recent Advances in miRNA and Functional Foods against Ionizing Radiation

LU Jike, CHEN Pei, CAO Nana, CHEN Chen, YI Juanjuan, HAO Limin   

  1. (1. School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China; 2. The Quartermaster Research Institute of Engineering and Technology, Academy of Military Sciences People’s Liberation Army China, Beijing 100010, China)
  • Online:2020-08-15 Published:2020-08-19

摘要: 食用辐射防护功能食品是预防保护电离辐射损伤的一条有效途径。MicroRNAs(miRNAs)是一类在真核生物中广泛存在的调控基因表达的内源性非编码RNA,其与辐射防护密切相关。食品摄入是生物体与外界进行物质、能量和信息交换的一种方式。特定的饮食包括功能食品因子会影响miRNAs的表达,并且这种影响可能具有传代作用。MicroRNA-34a(miR-34a)在电离辐射防护中发挥重要作用,miR-34a/Sirt1/p53信号通路与辐射防护功能食品的关系值得关注和进一步深入研究。

关键词: 电离辐射, miRNAs, 辐射防护, 辐射防护剂, 功能食品

Abstract: Consumption of functional foods against radiation is an effective way to protect against ionizing radiation damage. MicroRNAs (miRNAs) are endogenous non-coding RNAs regulating gene expression found in many eukaryotic organisms, and they are closely related to radiation protection. Food intake is a way of exchanging material, energy and information between organisms and the environment. Specific diets, including functional food factors, can affect the expression of miRNAs, and this effect may be transgenerational. MicroRNA-34a (miR-34a) plays an important role in protection against ionizing radiation, and the relationship between the signal pathway of miR-34a/Sirt1/p53 and functional foods against radiation deserves concern and needs to be further studied.

Key words: ionizing radiation, miRNAs, radiation protection, radioprotectants, functional foods

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