食品科学 ›› 2018, Vol. 39 ›› Issue (7): 263-269.doi: 10.7506/spkx1002-6630-201807039

• 专题论述 • 上一篇    下一篇

食品中甲基乙二醛的来源、毒性及其清除剂研究进展

过利敏1,2,张文生1,3,*,李士明4,*   

  1. 1.北京师范大学地理科学学部,中药资源保护与利用北京市重点实验室,北京 100875; 2.新疆农业科学院农产品贮藏加工研究所,新疆 乌鲁木齐 830091; 3.北京师范大学地理科学学部,天然药物教育部工程研究中心,北京 100875; 4.黄冈师范学院 经济林木种质改良与资源综合利用湖北省重点实验室,湖北 黄冈 438000
  • 出版日期:2018-04-15 发布日期:2018-04-17
  • 基金资助:
    国家自然科学基金面上项目(31571832;81771152)

Progress in the Generation and Health Risks of Methylglyoxal in Foods and Methylglyoxal-Scavenging Agents from Natural Products

GUO Limin1,2, ZHANG Wensheng1,3,*, LI Shiming4,*   

  1. 1. Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China; 2. Institute of Agro-production Storage and Processing, Xinjiang Academy of Agricultural Sciences, ürümqi 830091, China; 3. Engineering Research Center of Natural Medicine, Ministry of Education, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China; 4. Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources, Huanggang Normal University, Huanggang 438000, China
  • Online:2018-04-15 Published:2018-04-17

摘要: 生物体内存在多种活性羰基化合物(reactive carbonyl species,RCS),其中甲基乙二醛(methylglyoxal, MG)是人体内最主要的RCS,它是机体内源性代谢产物,也能在食品加工和贮藏过程中产生,尤其在含糖量高的 焙烤食品和加入高果糖玉米糖浆的碳酸饮料中含量较高。除了具有直接的细胞毒性,MG也参与体内蛋白质和核酸 的糖化反应,引起羰基应激,诱发组织病理损伤,加剧慢性退行性疾病的恶性发展。本文概述了食品加工中MG的 产生、健康危害及其清除等方面的国内外研究进展,为清除MG功能食品的研发提供理论依据。

关键词: 甲基乙二醛, 活性羰基化合物, 功能食品, 甲基乙二醛清除

Abstract: Methylglyoxal (MG) is one of the most potent active carbonyl compounds harmful for human health. MG as an endogenous metabolite exists in foods, especially processed foods and beverages containing sugar or high fructose corn syrup. MG has a direct cytotoxicity and can participate in the glycation of proteins and nucleic acids, triggering carbonyl stress and consequently inducing pathological status and even exacerbateing the development of chronic degenerative diseases. Herein, we summarize the mechanism of MG generation during food processing and its pathological risks, especially the types, structure and reactivity of MG trapping agents from edible plants. The aim is to provide a theoretical evidence for finding natural, effective and efficacious MG scavenging agents for the development of functional foods.

Key words: methylglyoxal, reactive carbonyl species, functional foods, methylglyoxal scavenging

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