食品科学 ›› 2022, Vol. 43 ›› Issue (11): 355-363.doi: 10.7506/spkx1002-6630-20210604-058

• 专题论述 • 上一篇    下一篇

黄嘌呤氧化酶肽类抑制剂的研究进展

袁禛,程述震,吴迪,林泽鑫,杜明   

  1. (1.大连工业大学食品学院,国家海洋食品工程技术研究中心,辽宁 大连 116034;2.大连工业大学,海洋食品精深加工省部共建协同创新中心,辽宁 大连 116034;3.中国农业大学食品科学与营养工程学院,北京 100083)
  • 出版日期:2022-06-15 发布日期:2022-06-30
  • 基金资助:
    兴辽领军人才项目(XLYC1802047)

Advances in Research on Xanthine Oxidase Inhibitory Peptides

YUAN Zhen, CHENG Shuzhen, WU Di, LIN Zexin, DU Ming   

  1. (1. National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China; 2. Collaborative Innovation Center of Provincial and Ministerial Co-construction for Marine Food Deep Processing, Dalian Polytechnic University, Dalian 116034, China; 3. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China)
  • Online:2022-06-15 Published:2022-06-30

摘要: 痛风是由于嘌呤类物质代谢增加或尿酸排泄异常引起的一种反复发作的炎症性疾病。在嘌呤类物质代谢成尿酸的过程中,黄嘌呤氧化酶(xanthine oxidase,XO)是调控尿酸生成的关键酶,其作用是将次黄嘌呤转化成黄嘌呤,将黄嘌呤转化成尿酸。通过抑制XO的活力可以抑制尿酸的生成,缓解高尿酸血症。近年来,蛋白来源的小分子降尿酸肽具有制备成本低、安全性高、易吸收、高活性、高稳定性和特异性等特点,已引起研究者的关注。本文首先对XO进行介绍,然后概括了XO分离鉴定的通用步骤,归纳总结了研究发现的混合肽类抑制剂及单一肽类抑制剂,并找到这些抑制剂的结构共性。为研究者发现新的XO肽类抑制剂提供思路和方向。

关键词: 肽;痛风;尿酸;黄嘌呤氧化酶;抑制剂

Abstract: Gout is a recurrent inflammatory disease caused by increased metabolism of purines or abnormal uric acid excretion. Xanthine oxidase (XO) is the key enzyme that regulates the generation of uric acid during the metabolism of purines into uric acid. Its function is to convert hypoxanthine into xanthine and into uric acid. By inhibiting the activity of XO, the production of uric acid can be inhibited, thereby relieving hyperuricemia. In recent years, small molecule uric acid-lowering peptides derived from proteins have attracted the attention of researchers because of their low preparation cost, high safety, easy absorption, and high activity, stability and specificity. This paper presents an overview of XO, and summarizes the general steps for the isolation and identification of XO, summarizes recently discovered mixed and single peptide inhibitors of XO with a special reference to the structural commonness of these inhibitors. This review will hopefully provide novel ideas and directions for researchers to discover new XO inhibitory peptides.

Key words: peptide; gout; hyperuricemia; xanthine oxidase; inhibitor

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