糖类与甜味剂肠-脑轴效应研究进展及评估方法分析

摘要/Abstract

摘要： 尽管甜味剂能够提供类似于糖类的风味感受和远高于糖类的甜味强度，但仍旧不能完全替代糖类所带来的满足感，明确该现象的生物学机制，对于完善甜味剂的功能评估体系和指导甜味剂的创新发展方向都具有十分重要的意义。本文系统综述了糖类与甜味剂引发的动物行为偏好差异、动物脑区活动差异和肠-脑轴神经激活模式差异等三个方面的研究进展，展现了大脑可以辨别糖和甜味剂从而产生个体行为偏好差异的深层原因，提出动物行为学、脑区神经活动和关键受体激活能力等三个层面可用于甜味剂肠-脑轴效应评估的技术手段，旨在为甜味剂领域的创新发展提供参考。

关键词: 糖类, 甜味剂, 肠-脑轴, 行为学偏好, 神经活动

Abstract: Sweeteners cannot completely replace the satisfaction provided by carbohydrates, even though they offer a similar flavor perception and much higher sweetness intensity than sugars. Clarifying the biological mechanism of this phenomenon is important to improve the function evaluation system of sweeteners and promote sweetener innovation. Herein, we reviewed the advances of research on the differences induced by sugars and sweeteners in three aspects: the behavioral preferences of the animals, the activity of the brain regions, and the activation patterns of the gut-brain axis. The underlying reasons for the brain to discriminate sugars and sweeteners, resulting in differences in behavioral preferences, are demonstrated. Finally, approaches of three levels, such as animal behavior, neural activity in brain regions, and critical receptor activation capacity, were proposed for the assessment of the sweeteners’ gut-brain axis effects.

Key words: sugar, sweetener, gut-brain axis, behavioral preferences, neural activity

中图分类号:

TS201.1

史清照刘富强张启东范武柴国璧毛健王焕丽姬凌波冯伟华宗国浩曹培健卢鹏谢剑平. 糖类与甜味剂肠-脑轴效应研究进展及评估方法分析[J]. 食品科学.

Wu FAN Guobi Chai. Progress in the Gut-brain Axis Effects of Carbohydrates and Sweeteners and Analysis on the Evaluation Methods[J]. FOOD SCIENCE.

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