FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (23 ): 410-414.doi: 10.7506/spkx1002-6300-200923092

Previous Articles     Next Articles

Effect of Fibrinolytic Compound on Fibrinolysis in Rats

QU Jia-hua1,TIAN Hong2,WU Wen-hui1,HAO Fei1,BAO Bin1,*   

  1. 1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 200090, China;
    2 Chifeng Pharmaceutical Co. Ltd., Chifeng 024001, China
  • Received:2009-08-16 Online:2009-12-01 Published:2010-12-29
  • Contact: BAO Bin E-mail:bbao@shou.edu.cn

Abstract:

The effect of compound MTP on induced clotlysis and its possible mechanism were investigated on the experimental model of pulmonary thrombosis in rat with fibrin labeled with FITC. The histological specimens of rat lung tissue were prepared and the degradation of FITC-labeled fibrin was analyzed by SDS-PAGE. The results showed that MTP was able to enhance fibrinolysis in vivo. It was speculated that compound MTP could enhance intrinsic activity of prourokinase as a plasminogen activator in a rat pulmonary embolism model.

Key words: pulmonary thrombotic model, MTP, histological section, SDS-PAGE, fibrinolysis

CLC Number: