Abstract:

The aim of this research was to investigate the anti-inflammatory and analgesic effects and acute toxicity of extract from Tartary Buckwheat seed (TSE). The animal models were established through dimethylbenzene-induced mice and rat inflammatory models with egg white injection under the aponeurosis. The pain models were obtained by hot plate and acetic acid in mice.The maximum administration dosage of TSE were determined via i.g. route in mice. TSE was able to significantly inhibit the mice ear edema induced by dimethylbenzene and the rat hind paw edema induced by egg white. The pain in mice caused by acetic acid and hot plate were evidently suppressed by TSE. The maximum administration dosage was 374.5g of TSE given to mice per kilogram, equivalent to 1498 times of the daily administration dosage of human body. TSE has obvious anti-inflammation and analgesia effect and no apparent toxicity.

Key words: tartary buckwheat, anti-inflammatory, analgesic, acute toxicity