Protective Effects of Some Polyphenol Compounds on Human Hepatocyte Damages Induced by Hydrogen Peroxide or Carbon Tetrachloride

doi:10.7506/spkx1002-6630-200903059

FOOD SCIENCE ›› 2009, Vol. 30 ›› Issue (3): 262-266.doi: 10.7506/spkx1002-6630-200903059

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Protective Effects of Some Polyphenol Compounds on Human Hepatocyte Damages Induced by Hydrogen Peroxide or Carbon Tetrachloride

ZHANG Xin，ZHAO Xin-huai*

(Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural
University, Harbin 150030, China)

Received:2008-02-12 Revised:2008-09-01 Online:2009-02-01 Published:2010-12-29
Contact: ZHANG Xin， E-mail:zhangxindoreen@163.com

Abstract

Abstract:

The potential hepatoprotective effects of five polyphenols, such as tea polyphenol, gallic acid, quercetin, kaempferol, apigenin and α-tocopherol (as a control) against oxidation damages of human hepatocyte induced by hydrogen peroxide or carbon tetrachloride were evaluated. The results showed that pre-treatment of hepatocytes with polyphenols at concentrations of 5, 10 and 20 mg/L for 1 h not only improve cell viability and the content of GSH, but also reduce LDH leakage and the formation of MDA in cells. The hepatoprotective effects of polyphenol compounds decrease in the following order: gallic acid > quercetin > tea polyphenol > apigenin > α-tocopherol > kaempferol. The protective mechanism may be associated with the high free radicalscavenging activity of polyphenlos.

Key words: polyphenol compounds, hepatocyte, induced damage, hydrogen peroxide, carbon tetrachloride

CLC Number:

TS202.3

ZHANG Xin，ZHAO Xin-huai*. Protective Effects of Some Polyphenol Compounds on Human Hepatocyte Damages Induced by Hydrogen Peroxide or Carbon Tetrachloride[J]. FOOD SCIENCE, 2009, 30(3): 262-266.

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Protective Effects of Some Polyphenol Compounds on Human Hepatocyte Damages Induced by Hydrogen Peroxide or Carbon Tetrachloride

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