Abstract:

Objective: To investigate anti-inflammatory effects and action mechanisms of aqueous extract of Fritillaria ussuriensis Maxim., snow pear juice and Pingbei Xueli Yin (BLY). Methods: Animal models of auricular edema induced by xylene in mice, capillary permeability induced by acetic acid in mice and paw edema induced by albumen in rats were established to observe anti-inflammatory effects of aqueous extract of Fritillaria ussuriensis Maxim., snow pear juice and BLY. The contents of PGE2 and MDA in inflammatory exudates were measured to explore anti-inflammatory mechanisms of three samples. Results: Aqueous extract of Fritillaria ussuriensis Maxim., snow pear juice and BLY exhibited good attenuation effects on auricular edema induced by xylene, paw edema induced by albumen and permeability increase of capillary induced by acetic acid. Meanwhile, the three experimental samples revealed an obvious inhibition effect on the increase of PGE2 and MDA. Moreover, snow pear juice and BLY exhibited an obvious dose-dependent inhibition effect on the increase of PGE2 and MDA. Conclusion: All of them have a good anti-inflammatory effect. A synergistic effect of Fritillaria ussuriensis Maxim. and snow pear juice on anti-inflammation is achieved. The three administration samples all had a negative regulation function on the level of PGE2 and MDA, which suggests that the anti-inflammatory effect might be related to the reduction of PGE2 and MDA levels.

Key words: aqueous extract of Fritillaria ussuriensis Maxim., snow pear juice, BLY, anti-inflammatory effect