Abstract:

Objective:To study the hypoglycemic effects of garlic oil and onion oil on diabetic mice. Methods: The diabetic mice induced by alloxan in different groups were fed with different dose of garlic oil or onion oil for 30-day continuously. Fasting blood glucose was determined on day 0 and 30, while glucose tolerance level was determined on day 30. The blood samples of mice were collected for the analysis of glycosylated serum protein and blood urea nitrogen as well as lipid levels. Results: There were significant differences between the diabetic mice given garlic oil or onion oil at the dose of 92.6 mg/(kg bw·d) and model group mice on the levels of fasting blood glucose, glucose area under curve, the levels of blood urea nitrogen, glycosylated serum protein (P＜0.05). Further more, garlic oil and onion oil at the dose of 92.6 mg/(kg bw·d) had protection on liver, kidney and pancreatic damage in diabetic mice. Conclusion: The garlic oil and onion oil had the hypoglycemic effects on diabetic mice, and they also had protective effects on liver and kidney as well as pancreatic injury caused by diabetes mellitus.

Key words: Alloxan, diabetic mice, garlic oil, onion oil, hypoglycemic effects