Abstract: In order to exploit the medicinal value of white radish, the effect of white radish extract on the amelioration of nonalcoholic fatty liver diseases in SD rats was explored. The white radish extract was prepared with a rotary evaporator. The rats in model group were treated with fat emulsion with white radish extract by gavage at the doses of 0.3, 1 mL/kg and 3 mL/kg. The pathological characteristics of liver tissues in rats with 8 weeks experiments were analyzed. Meanwhile, serum lipid and lipid peroxidases were determined. The results indicated that white radish extract at a high dose could significantly decrease the levels of serum TG and MDA and increase the levels of GSH in male rats. Moreover, white radish extract could alleviate the accumulation of lipid in the hepatocytes of male rats. However, no obvious change of these parameters in female rats was observed. Therefore, white radish extract can ameliorate nonalcoholic fatty liver diseases in SD male rats by decreasing the level of lipid peroxidation.

Key words: nonalcoholic fatty liver disease, white radish extract, pathological diagnosis