Immunomodulatory Effect of Polysaccharides from Mulberry Leaves (PML) in Mice

doi:10.7506/spkx1002-6630-201113060

Abstract

Abstract: Objective: To explore the effect of polysaccharides from mulberry leaves (PML) on the immune function of mice. Methods: KM mice were administered with polysaccharides from mulberry leaves at the doses of 125, 250 mg/(kg ·d) and 500 mg/(kg ·d) by gavage for 30 consecutive days. The mice in blank group were administered with the same volume of saline. After the administration for 30 days, carbon clearance test, serum hemolysin determination, spleen lymphocyte transformation test and organ index (thymus and spleen) were investigated to explore the effect of PML on the immune function of mice. Results: At the investigated doses, PML could significantly improve carbon clearance capacity and spleen lymphocyte transformation capability induced by ConA. In low dose group, PML could significantly increase the thymus index. Conclusion: PML can enhance the immune function of mice.

Key words: mulberry leaves, polysaccharides, immunomodulation

CLC Number:

O629.12

Nurgul·RAHMAN，CHEN Xiao-hong，Gulsum·TOHSUN，DONG Ming-sheng,. Immunomodulatory Effect of Polysaccharides from Mulberry Leaves (PML) in Mice[J]. FOOD SCIENCE, 2011, 32(13): 280-283.

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Immunomodulatory Effect of Polysaccharides from Mulberry Leaves (PML) in Mice

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