Effects of trans-Fatty Acids on Damage of Human Umbilical Vein Endothelial Cells

doi:10.7506/spkx1002-6630-201119055

Abstract

Abstract: The effects of trans-linoleic acid and trans-oleic acid on survival rate, nitric oxide synthase (NOS) activity, nitric oxide (NO) production and lactate dehydrogenase (LDH) leakage of human umbilical vein endothelial cells was studied to explore the mechanisms by which trans-fatty acids promote atherosclerosis. The results showed that both trans-fatty acids could inhibit cell proliferation through reducing NOS activity and NO secretion, increasing LDH leakage, and decreasing the vasodilation capability, thus affecting the cell oxidative stress level. Moreover, trans-linoleic acid revealed stronger cell damage than trans-oleic acid.

Key words: trans-linoleic acid, trans-oleic acid, human umbilical vein endothelial cells, damage

CLC Number:

R151.2

YU Hua-hong，LIANG Zhong-shuang，LI Xiang-mei，QIU Bin，LIU Rong，LI Jing，DENG Ze-yuan. Effects of trans-Fatty Acids on Damage of Human Umbilical Vein Endothelial Cells[J]. FOOD SCIENCE, 2011, 32(19): 244-247.

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Effects of trans-Fatty Acids on Damage of Human Umbilical Vein Endothelial Cells

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