FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (23): 285-288.doi: 10.7506/spkx1002-6630-201123057

• Nutrition & Hygiene • Previous Articles     Next Articles

Antioxidant Activity of Polysaccharide FUP-1 from Fritillaria ussuriensis Maxim in D-Galactose-induced Aging Mouse Model

LIU Chun-hong1，KIM Jong-du2，HAN Bao-rui3，*   

  1. (1. Special Education College of Changchun University, Changchun 130022, China；2. Dongbang Graduate University, Seoul 136823, Korea；3. Development College of Jilin Agricultural University, Changchun 130600, China)
  • Online:2011-12-15 Published:2011-12-21

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Abstract: To investigate the antioxidant activity of polysaccharide isolated from Fritillaria ussuriensis Maxim (FUP-1) on senescent mice induced by D-galactose, mice were induced senescence by consecutive injection of D-galactose (500mg/kg/d)) once daily for 7 weeks and fed Vitamin E and different doses of F. ussuriensis polysaccharide. Antioxidant activity in liver and serum, and anti-aging activity in brain were measured. The results showed that the F. ussuriensis polysaccharide could significantly improve general appearance of the aging model mice. In comparison with the aging model group, the activities of superoxide dismutase (SOD) in serum, total anti-oxidative capacity (T-AOC) and glutathione peroxidase (GSH-Px) activities in liver of the two FUP-1 groups were increased and the malondialdehyde (MDA) levels in liver were decreased. FUP-1 treatment significantly decreased monoamine oxidase (MAO) activities of brain in D-galactose treated mice. In conclusion, FUP-1 has antioxidant activity on aging model mice and the mechanism may be related to the enhancement of activity of antioxidases and the reduction of lipid peroxidation.

Key words: Fritillaria ussuriensis, polysaccharide, anti-aging, antioxidant

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