Abstract: Objective: To explore the effect of persimmon fruit polyphenol on lipid metabolism of hyperlipidemia mice. Methods: Totally 80 mice were divided into 7 groups including normal control group A and B, high blood fat group, persimmon fruit polyphenol groups at high, middle and low dosages and positive control group were treated with different supplementations after the hyperlipidemia mouse model had been established through high fat diet. Levels of serum total cholesterol (TC), total triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), lipid peroxides (LPO), hepatic free fatty acid (FFA), superoxide dismutase (SOD), lipoprotein lipase (LPL) and hepatic lipase (HL) in mice were evaluated. Results: Persimmon fruit polyphenol could remarkably reduce the levels of serum TC, TG, LDL-C, LPO and hepatic FFA (P＜0.01), slightly increase the level of HDL-C and notably improve the activities of SOD, LPL and HL (P＜0.01). Conclusion: Persimmon fruit polyphenol could alleviate hyperlipidemia by regulating lipid metabolism of mice, thus preventing arteriosclerosis(AS).

Key words: persimmon fruit polyphenol, hyperlipidemia, lipid metabolism, plasma lipid reduction, arteriosclerosis