Optimization of Lubricant Typye and Amount in Seaweed Polysaccharide-Inulin Effervescent Tablets
by Response Surface Methodology

doi:10.7506/spkx1002-6630-201212018

FOOD SCIENCE ›› 2012, Vol. 33 ›› Issue (12): 93-96.doi: 10.7506/spkx1002-6630-201212018

• Processing Technology • Previous Articles Next Articles

Optimization of Lubricant Typye and Amount in Seaweed Polysaccharide-Inulin Effervescent Tablets by Response Surface Methodology

PU Yang1,2，FENG Da-wei1，BAO Huan-ling3，QIN Song1，YI Yue-tao1,*

(1. Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China；2. Graduate University of Chinese Academy of Sciences, Beijing 100049, China；3. Shandong Oriental Ocean Sci-tech Co. Ltd., Yantai 264003, China)

Online:2012-06-25 Published:2012-07-27

Abstract

Abstract: Effervescent tablets were prepared from organic selenium-enriched seaweed polysaccharides and inulin by absolute alcohol-acid-base two-phase granulation method. Using response surface methodology based on a three-variable, three-level central composite design, the amounts of the added lubricants sodium dodecylsulfate, magnesium stearate, and silica powder in effervescent tablet formulation were optimized to be 0.70%, 2.60% and 0.90%, respectivley. All the quality indexes fhe prepared effervescent tablets complied with the requirements of the Chinese Pharmacopoeia.

Key words: effervescent tablets, optimum formulation, inulin, organic selenium-enriched seaweed polysaccharide

CLC Number:

TS218

PU Yang，FENG Da-wei，BAO Huan-ling，QIN Song，YI Yue-tao. Optimization of Lubricant Typye and Amount in Seaweed Polysaccharide-Inulin Effervescent Tablets by Response Surface Methodology[J]. FOOD SCIENCE, 2012, 33(12): 93-96.

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Optimization of Lubricant Typye and Amount in Seaweed Polysaccharide-Inulin Effervescent Tablets by Response Surface Methodology

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