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Preventive Effect of Procyanidins from Lotus Seedpod on Hippocampal Neurons Injury Induced by Extremely Low Frequency Electromagnetic Field

ZHANG Hai-hui1，WU Yan1，ZHANG Rui1， ZHANG Shuang1， DUAN Yu-qing1,*，SUN Gui-bo2，SUN Xiao-bo2   

  1. 1. School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China；
    2. Institute of Medicinal Plants, Chinese Academy of Medical Sciences, Beijing 100193, China
  • Online:2013-07-15 Published:2013-06-28
  • Contact: DUAN Yu-qing

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Abstract:

To investigate the preventive effect of procyanidins from lotus seedpod (LSPC) on hippocampal neuron injury induced
by extremely low frequency electromagnetic fields (ELF-EMF), primary cultured hippocampal neurons from rats were pretreated
with LSPC before exposure to ELF-EMF. Survival rates, the morphology of neurons and the level of reactive oxygen species
(ROS) were measured. The survival rates of hippocampal neurons pretreated with LSPC (2.5, 5 μg/mL and 10 μg/mL) were
81.23%, 90.18% and 93.45%, respectively, which were significantly higher than those from the model group (66.88%,
P ＜ 0.05). Electromagnetic radiation increased the ROS level in neurons (the fluorescence intensity was (228.19 ± 16.28), while
pretreatment with 2.5, 5, 10 μg/mL of LSPC reduced ROS level obviously (P ＜ 0.05). All these studies indicated
pretreatment with LSPC could significantly block hippocampal neuron injury induced by extremely low frequency
electromagnetic field.

Key words: extremely low frequency electromagnetic field, hippocampal neuron, procyanidins from lotus seedpod (LSPC), reactive oxygen species (ROS)

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