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Hypoglycemic Effect of Total Flavonoids from Gynura divaricata Roots and Rhizomes in Diabetic Rats

YU Hao,MAO Bin-bin,ZHOU Guo-liang,FANG Yan-xi   

  1. Food and Drug College, Anhui Science and Technology University, Fengyang 233100, China
  • Online:2013-08-15 Published:2013-09-03
  • Contact: YU Hao

Abstract:

Objective: To observe the hypoglycemic effect of total flavonoids from Gynura divaricata roots and rhizomes in
diabetic rats. Methods: Diabetic rat model was induced by injecting streptozotocin in vena caudalis. The body weight, food
intake, water intake, urine and fasting blood glucose (FBG) were measured. The levels of glycosylated hemoglobin (GHB),
triglyceride (TG), cholesterol (CH), superoxide dismutase (SOD) and malondialdehyde (MDA) in serum were determined,
and the pathological change of the pancreas was also observed. Results: Total flavonoids from Gynura divaricata roots and
rhizomes could reduce food intake, water intake, urine and FBG, decrease GHB, TG and CH in serum, improve SOD activity
in serum, and decrease MDA content in serum. Meanwhile, the pathological change of pancreatic tissue was attenuated.
Conclusion: Total flavonoids from Gynura divaricata roots and rhizomes can improve hyperglycemia of diabetic rats, and
its mechanisms may be related to the improved lipid metabolism, anti-lipid peroxidation, and inhibition of the pathological
change in pancreatic tissue.

Key words: total flavonoids from Gynura divaricata roots and rhizomes, diabetic rats, fasting blood glucose, lipid peroxidation

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