Abstract:

In this study, the hop polyphenol extract (HPE, 88.7% purity) obtained from the supercritical CO2 raffinate
of waste hops from beer brewing was evaluated for hypolipidemic and antioxidant effects in hyperlipidemia mice in
comparison with tea polyphenols at the same dose. The hyperlipidemia mice were orally administered with HPE at doses of
200–800 mg/(kg·d) for five weeks. The results showed that total cholesterol and triglyceride contents in serum and liver,
low-density lipoprotein cholesterol level in serum, and atherogenic index in hyperlipidemia mice were decreased
significantly in response to HPE administration. Meanwhile, the serum level of high-density lipoprotein cholesterol was
significantly increased. In addition, the contents of malondialdehyde in blood and liver were significantly reduced, and
catalase activities were significantly enhanced. Superoxide dismutase activities in red blood cells and liver, and glutathione
peroxidase activities in blood and liver were significantly elevated. Therefore, HPE has significant hypolipidemic and
antioxidant effects in hyperlipidemic mice.

Key words: hop polyphenols, hyperlipidaemia, lipid peroxidation, mice