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Anti-fibrosis Effects of Long-term Oral Administration of Dietary Nucleotides in the Chronologically Aging Liver of Sprague-dawley Male Rats

XU Mei-hong,LI Yong*   

  1. Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
  • Online:2013-08-15 Published:2013-09-03
  • Contact: LI Yong

Abstract:

Purpose: To investigate the anti-fibrosis effects of dietary nucleotides on aging liver and explore their
possible mechanisms. Methods: Liver samples from rats at the age of 24-26 months (aged control, 0.01% NTs and
0.64% NTs; n = 6/group) were excised for analysis. Another group of male SD rats (n = 8) which were fed the control diet
were sacrificed at the age of 12 months to be used as middle aged controls. The liver samples were used for investigation on
Hyp level, as well as the expression levels of miRNA and their target genes. Results: This study established the association
of miR-182 and miR-328a* with NTs in aging liver, meanwhile highlighted the correlation of miRNA expression with their
target genes Thbs-2 and Pdgf-b. This study also identified that long term administration of NTs inhibited the age related
increase of Hyp level in the chronologically aged liver. Conclusions: The present study demonstrated that the anti-fibrosis
effects of long-term NTs on chronological liver aging. It is possible because NTs affect miR-182 and miR-328a* through
their target genes Thbs-2 and Pdgf-b in the aged liver of SD male rats.

Key words: dietary nucleotides (NTs), aging liver, miRNA

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