Abstract: Alzheimer’s disease (AD), an age-related neurodegenerative disease, can seriously affect the health of the elderly. Since the pathogenesis of AD is very complex, the commonly used drugs in clinical practice against AD can attenuate the symptoms of mild to moderate AD, but cannot prevent, terminate or reverse the progression of AD. Therefore, natural products that can prevent and treat AD have gained great attention, and the majority of studies have confirmed that natural products can improve two major pathological features of AD, senile plaques and neurofibrillary tangles. Recently, accumulating studies have demonstrated that natural products function to prevent and treat AD through regulating miRNA and autophagy, which will be beneficial for establishing novel and effective strategies for the prevention and treatment of AD in the future.

Key words: autophagy, miRNA, Alzheimer’s disease, natural products