Effect of Lactosucrose on Plasma Th1/Th2 Type Cytokines in Rats with Colonitis

doi:10.7506/spkx1002-6630-201317050

Abstract

Abstract:

Objective: To explore effect of lactosucrose (LS) on blood immunity and Th1/Th2 type cytokines in rats with
colonitis. Methods: Experimental rat colitis was induced by trinitrobenzenesulfonic acid (TNBS) and randomly distributed
into three groups as follows: model control (MC) group, LS group and SASP group. The normal control (NC) group was
also included. All rats were killed on the 21st day. The activities of alkaline phosphatase (ALP), lactate dehydrogenase (LDH)
and inducible nitric oxide synthase (iNOS), and the contents of IFN-γ, IL-4 and IL-10, as well as IFN-γ/IL-4 ratio were
measured in experimental colitis rats. Results: Compared with NC group, the activity of ALP and the content of IFN-γ were
significantly increased (P ＜ 0.01) and the content of IL-4 was significantly decreased (P ＜ 0.01) in MC group. Moreover,
the content of IL-10 was significantly decreased (P ＜ 0.05), the activities of LDH and iNOS and IFN-γ/IL-4 ratio were
significantly increased (P ＜ 0.05). Compared with MC group, the activity of ALP and the contents of IL-4 and IL-10 in
LS group were significantly increased, and the activity of iNOS and the ratio of IFN-γ/IL-4 were significantly decreased.
Conclusion: The mechanism of LS in relieving inflammation in colitis may be achieved by increasing Th2 type cytokine
production and rebalancing the Th1/Th2 immune response.

Key words: lactosucrose, inflammatory bowel disease, Th1/Th2 balance, cytokine

CLC Number:

TS218
R151.3

ZHOU Yan1,2，RUAN Zheng1,2,*，HUANG Xiao-liu1,2，LI Ling1,2，LIU Wen-qun1,2，WEN Yan-mei1,2，MI Shu-mei1,2，WU Xin1,2,3，YIN Yu-long1,2,3. Effect of Lactosucrose on Plasma Th1/Th2 Type Cytokines in Rats with Colonitis[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201317050.

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Effect of Lactosucrose on Plasma Th1/Th2 Type Cytokines in Rats with Colonitis

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