Inhibitory Effect of Rosmarinic Acid on Nitration of Insulin

doi:10.7506/spkx1002-6630-201419044

Abstract

Abstract:

Objective: To investigate the effect of rosmarinic acid (RA) on the nitration of insulin induced by peroxynitrite anion
(ONOO－). Methods: The insulin was incubated with excessive amounts of ONOO－ in a chemical system with or without
RA. The nitrated insulin was detected by colorimetric method and non-denaturing polyacrylamide gel electrophoresis (native-
PAGE). Results: Insulin could be nitrated by ONOO－ and the nitrated insulin had the maximum absorption peak at 396 nm.
RA inhibited insulin nitration induced by excessive ONOO－ in a concentration-dependent manner, whereas it had no effect on
thenitrated insulin. Conclusion: RA can inhibit insulin nitration, which may be due to its scavenging activity on ONOO－.

Key words: rosmarinic acid, insulin, nitration, peroxynitrite anion

CLC Number:

R966

XU Xiao-min, SUN Pei-huan, QIU Li-hong, YAO Wen, GAI Zhi-liang, XIE Jian-xin, XU Bo, WANG Zhen-hua. Inhibitory Effect of Rosmarinic Acid on Nitration of Insulin[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201419044.

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Inhibitory Effect of Rosmarinic Acid on Nitration of Insulin

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