Abstract:

Aim: To investigate the effect of Lactobacillus plantarum NCU116 (L. plantarum NCU116) on antioxidant
activity and renal function in rats fed a high-fat diet. Methods: Totally 40 male rats were randomly divided into 4 groups:
L. plantarum NCU116 groups with two doses (108 and 109 CFU/mL), high-fat model group and normal control group. After
5-week administration, the renal index was analyzed, and the contents of serum creatinine (Scr), blood urea nitrogen (BUN),
and uric acid (UA) were determined. Meanwhile, the activities of superoxide dismutase (SOD), glutathione peroxidase
(GSH-Px), and catalase (CAT), total antioxidant capacity (T-AOC) and the content of malondialdehyde (MDA) in renal
homogenates were determined. The kidney was examined histopathologically as well. Results: Compared with highfat
model group, the levels of UA, SOD, GSH-Px, CAT, T-AOC, and MDA in the high-dosage L. plantarum NCU116
group were obviously improved (P ＜ 0.05), and these biochemical observations were supplemented by histopathological
examination of the kidney. Conclusion: L. plantarum NCU116 can protect the kidney from oxidative stress and improve the
renal function of high-fat diet fed rats.

Key words: Lactobacillus plantarum NCU116 (L. plantarum NCU116), high-fat diet, oxidative stress, renal function