Sedative and Hypnotic Effects of the Extracts from Nelumbo nucifera Leaves

doi:10.7506/spkx1002-6630-201505032

Abstract

Abstract:

Objective: The present study aimed to determine the sedative and hypnotic effects of 50% ethanol extract and
its different fractions prepared from Nelumbo nucifera leaves. Methods: Locomotion activity and pentobarbital-induced
sleeping tests were used to evaluate the sedative and hypnotic activities of 50% ethanol extract (150 and 450 mg/kg) and
different fractions (30 and 90 mg/kg) through gavage administration. Results: Ethanol extract (450 mg/kg) and alkaloid
fraction (30 and 90 mg/kg) significantly inhibited the locomotion activity of mice, increased the percentage of sleeping and
decreased the sleep latency and prolonged the sleeping time of mice. Conclusion: Nelumbo nucifera leaves possess sedative
and hypnotic effects and its alkaloids are the bioactive components for these activities.

Key words: Nelumbo nucifera leaves, sedative, hypnotic, alkaloids

CLC Number:

R285.5

YAN Mingzhu1,2, ZHONG Yu1,2, LIU Xinmin2, ZHANG Zesheng1, YE Linhu2, CAO Fangrui2, XIAO Bingxin2, FENG Li2, CHANG Qi2,*. Sedative and Hypnotic Effects of the Extracts from Nelumbo nucifera Leaves[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201505032.

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Sedative and Hypnotic Effects of the Extracts from Nelumbo nucifera Leaves

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