Abstract:

The main objective of this study was to evaluate the effect of high-dose N,N-dimethylglycine sodium (Na-DMG)
on growth performance, hematological parameters and blood physiobiochemical indices of broilers. Totally 480 one-day-old
Arbor Acres (AA) broiler chicks were randomly allocated to four groups with 6 replicates in each group, and fed commercial
diet supplemented with N,N-dimethylglycine sodium at doses of 1 500, 7 500 and 15 000 mg/kg, respectively, for
42 days, which was divided into early (1?21 d) and later (22?42 d) stages. The results showed that: 1) the dietary addition of
1 500 mg/kg N,N-dimethylglycine sodium could decrease the feed gain ratio of 21-day-old broilers significantly (P < 0.05).
N,N-dimethylglycine sodium at 15 000 mg/kg could result in the increased the feed gain ratio of 42-day-old broilers when
compared with 1 500 and 7 500 mg/kg (P < 0.05). Throughout the whole administration period, no significant difference
in feed gain ratio among the control group, 7 500 mg/kg and 15 000 mg/kg groups was observed (P > 0.05); (2) different
dose levels of dietary supplementation with N,N-dimethylglycine sodium had no significant difference in hematological
parameters of broilers when compared with the control group (P > 0.05); 3) feeding with 15 000 mg/kg N,N-dimethylglycine
sodium decreased blood total protein and albumin levels of 21-day-old broilers significantly when compared with the
control group (P < 0.05), while total bilirubin in the blood from the 15 000 mg/kg group was significantly higher than that
from the control, 1 500 mg/kg and 7 500 mg/kg groups (P < 0.01). In conclusion, the dietary addition of 15 000 mg/kg
N,N-dimethylglycine sodium can damage digestible absorption and liver function of broilers.

Key words: N,N-dimethylglycine sodium, broiler, growth performance, hematological parameters, blood physiochemical indices