Abstract:

Objective: To study the effect of walnut polypeptide on lipids in D-galactose induced senile dementia model mice.
Methods: The experimental mice were subjected to D-galactose treatment to establish sub-acute senile mouse models. The
amount or activity of lipids and antioxidant enzymes in serum and brain were tested. Results: In comparison with the model
group, the walnut polypeptide prepared by either of two specific-purpose enzymes for plant protein hydrolysis could decrease
the contents of TC, TG and LDL-C; in contrast, the walnut polypeptide prepared by alkaline protease could increased the
content of HDL-C. On the other hand, compared with the model group, all walnut polypeptides prepared in this study could
increase the activities of T-AOC and SOD. Moreover, the walnut polypeptide prepared by specific-purpose enzyme 1 could
decrease the content of MDA in brain. Conclusion: Walnut polypeptide can decrease the levels of blood lipids and increase
the antioxidant capacity in D-galactose-induced senile dementia model mice.

Key words: walnut polypeptide, D-galactose, lipids, mice