Migration Pattern of Trimethyltin from PVC Food Packaging Materials to Food Simulants

doi:10.7506/spkx1002-6630-201614035

Abstract

Abstract:

Objective: To develop an ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
method for determining trimethyltin (TMT) in polyvinyl chloride (PVC) food packaging materials and four food simulants
and to further study the migration pattern of TMT from the packaging materials to the food simulants. Methods: TMT
was extracted from PVC food packaging materials with ethyl acetate. After purification and enrichment with OASIS
MCX C18 cartridge, the eluate containing food simulants was evaporated to dryness with nitrogen in water bath, redissolved
with the mobile phase, vortexed and filtered through a 0.22 μm membrane. The filtrate was detected by
UPLC-MS-MS using positive ion electrospray ionization under multiple reaction monitoring (MRM) mode with a UPLC C18
column as separation column, and quantified by an external standard method. At different temperatures, PVC food packaging
materials were soaked in four food simulants, namely, water, 10% ethanol solution, 3 g/100 mL acetic acid solution and
n-hexane, respectively. At certain time points, the soaking solution was analyzed by UPLC-MS/MS. Results: The standard
calibration curve of TMT was linear in the range of 0.1–100.0 μg/L with a correlation coefficient of 0.999 8. The recoveries
at three spiked levels (1.0, 10.0 and 50.0 μg/L) ranged from 90.6% to 97.3%, with relative standard derivations (RSDs) lower
than 6.9%. TMT was detected in the range of 0.19–1.65, 0.19–9.89, 0.11–9.96 and 0.15–3.54 μg/L in water, 10% ethanol
solution 3 g/100 mL acetic acid solution and n-hexane, respectively. Conclusion: The solid phase extraction-UPLC-MS/
MS method is simple, reliable, accurate,and applicable to determinate TMT in food simulants. TMT in PVC food packaging
materials easily migrates to 10% ethanol solution and 3 g/100 mL acetic acid solution. These results showed that TMT
migration has positive correlations with temperature and time, but the process was balanced after a certain period of time.

Key words: ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), trimethyltin, food simulant, polyvinyl chloride (PVC), food packaging materials

CLC Number:

R155.5

XU Xinxin, CHEN Huiling, MAO Lisha, HU Xinnan. Migration Pattern of Trimethyltin from PVC Food Packaging Materials to Food Simulants[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201614035.

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