Response Surface Optimization of Preparation of Microencapsulated Quercetin Using Complex Coacervation and Its Physicochemical Properties

doi:10.7506/spkx1002-6630-201622004

Abstract

Abstract: Quercetin microcapsules were prepared by complex coacervation using sodium alginate and chitosan as the wall materials and quercetin as the core material. Single factor experiments and response surface methodology were employed to optimize the preparation conditions based on embedding rate and drug loading. The physicochemical properties of quercetin microcapsules were investigated as well. Under the optimized conditions: sodium alginate/chitosan ratio, 3.34:1; core/wall material ratio, 4.34:1; genipin concentration, 18.44 g/100 g chitosan; and curing temperature, 41.56 ℃, the embedding rate could reach 69.53%. The moisture content, repose angle and solubility of the quercetin microcapsules was 3.26%, 40.39° and 256.44 μg/mL, respectively. The encapsulated quercetin had good solubility and stability.

Key words: quercetin, complex coacervation, microencapsulation, physicochemical properties

CLC Number:

R151.2

LIAO Xia, YANG Xiaolan, LI Yao, WANG Liying, MING Jian,*. Response Surface Optimization of Preparation of Microencapsulated Quercetin Using Complex Coacervation and Its Physicochemical Properties[J]. FOOD SCIENCE, 2016, 37(22): 20-27.

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