Abstract: To evaluate the edible safety of prepared IgY. Some tests of acute oral toxicity, born marrow cell micronucleus, sperm shape abnormality in mice, Ames and thirty - day feeding were conducted in our study.The LD50 of all the rats and mice were more than 20ml/ kg bw, so the teeth protection spray belonged to actually non - toxicity; tests of born marrow cell micronucleus, sperm shape abnormality in mice, Ames were negative; The thirty - day feeding test in rats demonstrated that it had no distinctive effects on routine blood, body weight and biochemical index. The teeth protection spray was safe for edibility.

Key words: IgY, acute toxicity, heredity toxicity, thirty- day feeding