FOOD SCIENCE ›› 2006, Vol. 27 ›› Issue (12): 706-709.

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Effect of Dietary Nucleotides on the Intestinal Antioxidation of Mice

SHI Yong-hui,LI Shi-ying,QIAN Jia,DAI Hui,LE Guo-wei   

  1. 1.Key Laboratory of Food Science and Security, Ministry of Education, Southern Yangtze University, Wuxi 214036, China;2.Institute of Food Nutrition and Saftey, School of Food Science and Technology, Southern Yangtze University, Wuxi 214036, China
  • Online:2006-12-15 Published:2011-11-23

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Abstract: Objective: To study the effects of dietary nucleotides on anti-oxidation and its mechanism on newly weaned mice under stimulation. Method: To determine changes on hepatic and intestinal glutathione (GSH), superoxide dismutase(SOD), glutathione peroxidase(GSH-PX), malondialdehyde(MDA),alanine aminotransferase(ALT)and myeloperoxidase(MPO)by nucleotides free (NF) and nucleotides (NT) diet mice under lipopolysaccharide (LPS) induced oxidative response. Results: Hepatic and intestinal GSH, SOD, GSH-PX increased and MDA decreased with nucleotides supplement 4 and 18 hours after LPS stimulation. Conclusion: Dietary nucleotides can help to increase anti-oxidation, protect mice from injury under LPS stimulation. The mechanism might involve in dietary nucleotides saving glycin, glutamine and energy, which increase GSH and further increase SOD, GSH-PX activity.

Key words: nucleotides, lipopolysaccharide(LPS), glutathione(GSH), superoxide dismutase(SOD), glutathione peroxidase(GSH-PX), malondialdehyde(MDA), alanine aminotransferase(ALT), myeloperoxidase(MPO)