Abstract: In this work the effects of Lipoic acid(LA) on blood lipid metabolism and antioxidation capability of rats fed with high-fat diet were explored. 24SD rats were divided into 3 groups: control group,high-fat group and LA (0.1%)group. Results showed that high-fat diet can cause hyperlipidemia.The content of TG, TC, LDL-C in serum were decreased significantly in LA group while the content of HDL-C in serum increased significantly.In comparison with high-fat group, both activities of LPL, HL, SOD in serum and the content of T-AOC, GSH, MDA in both serum and tissue increased significantly in LA group. Moreover, LA could decrease atherosclerotic index(AI). Conclusions: LA has the function of reducing blood lipid and anti-lipid peroxidation, and preventing from atherosclerosis.

Key words: lipoic acid, hyperlipidemia, lipid peroxidation, atherosis