Abstract: Objective: Study on the effects of Prunella vulgaris L. extracts (PVE) on blood glucose、blood lipid in ICR diabetic mice. Methods: Diabetic models were induced by the i.v. injection of strepotozotocin (STZ) in ICR mice, and were divided into different groups, which were given 8g/kg PVE, 4g/kg PVE, glibenclamide or normal water respectively. Blood glucose, TC, TG, HDL-C, LDL-C and food, water intake and body weight were assaged. Result: After 28d drug administration, symptoms of diabetic mice fed PVE were alleviated obviously. PVE can decrease water, food intake of diabetic mice, and increase their body weight. High dose of PVE lowered the level of blood glucose by 9.7%, and two doses of PVE lowered the levels of TC, TG and LDL- C, but increased the level of HDL-C remarkably. PVE can have the potential hypoglycemic effect and alleviate the diabetic symptoms on diabetic mice.

Key words: Prunella vulgaris L, diabetes mellitus, ICR mice, blood glucose, blood lipid