Study on Inhibitory Effects of Spirulina platensis on Histamine Releasing from Sensitized Cells in vitro and in vivo

Abstract

Abstract: Inhibitory effects of Spirulina platensis (SP) on histamine released from sensitized cells stimulated in vitro and in vivo were investigated using guinea pig allergic model administrated with allergen ovalbumin (OVA). Histamine was determined by OPT fluorescence spectrophotometry. Results showed that the releasing rates of histamine both in whole blood and in peritoneal mast cells (PMC) of allergic guinea pig decrease obviously (p < 0.05) with SP supplement. The cell number of basophil (BAS) and eosinophil (EOS) in peripheral blood decreases also. Present data suggest that SP supplementation in dietary can inhibit sensitized cell-mediateda llergic reactions.

Key words: Spirulina platensis, allergen, histamine

HUANG Zhi, HUANG Wei-Wei. Study on Inhibitory Effects of Spirulina platensis on Histamine Releasing from Sensitized Cells in vitro and in vivo[J]. FOOD SCIENCE, 2007, 28(1): 296-298.

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Study on Inhibitory Effects of Spirulina platensis on Histamine Releasing from Sensitized Cells in vitro and in vivo

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