Toxic Effect of PQ on Rats and Embryo

Abstract

Abstract: The toxic effect of PQ on rats and fetus was studied in this paper. The results indicated that PQ cannot induce germinal mutation at the dose of 1/10 LD50, 1/5 LD50 and 1/2 LD50 and also cannot enhance the rat’s spermatic activity ratio or induce gential toxicity on rats at the dose of 1/40 LD50, 1/20 LD50 and 1/10 LD50. But PQ can affect the activity of AKP(ALP) by digestive tract at these doses; PQ can induce contraction of DA of embryo showing that PQ has embryonic toxicity; with the dose increasing, the inner diameter of DA decreasing, indicating that there is dose-reaction relationship between the dose and inner diameter of DA.

Key words: PQ, toxicity, rats, embryo

QUAN Wu-Rong, GUO Huan-Yu, REN Da-Yong, SHEN Ming-Hao. Toxic Effect of PQ on Rats and Embryo[J]. FOOD SCIENCE, 2007, 28(10): 510-513.

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Toxic Effect of PQ on Rats and Embryo

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