Abstract: Objective: To evaluate the effects of anthocyanin-rich extract from black rice on insulin resistance and hyperlipidemia amelioration in the fructose-fed rats test. Method: A total of 60 rats were randomly divided into five groups to receive 8-week diets as follows: regular diet; high-fructose diet; high-fructose diet preventively supplemented with 5 g of extract/kg diet; and the other two groups firstly received high-fructose diet for 4 weeks, then treated with 5 g of extract/kg diet or 270 mg of pioglitazone/ kg diet for the last 4 weeks. Results: The anthocyanin-rich extract prevents the development of fructose-induced insulin resistance, and significantly ameliorates the hyperlipidemia and insulin resistance in fructose-fed rats, but the extract fails to reverse the fructose-induced hyperinsulinemia as pioglitazone does.

Key words: anthocyanin, black rice, hyperlipidemia, insulin resistance, metabolic syndrome