FOOD SCIENCE ›› 2007, Vol. 28 ›› Issue (11): 529-532.

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Symptom and Mechanism of Low Molecular Chitooligosaccharides in II Type Diabetic Rats

 WANG  Xin, LIN  Qiang, TIAN  Ping-Fang, SANG  Shuai, GAO  Wei   

  1. 1.College of Biochemical Engineering, Beijing Union University, Beijing 100023, China; 2.College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
  • Online:2007-11-15 Published:2011-11-22

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Abstract: Objective: To investigate the influence of low molecular chitooligosaccharides(COS) in diabetic rats. Methods: Diabetic model was induced by injecting streptozotocin (STZ) and the rats were treated with high fat and sugar diet for four weeks. Rats were randomly divided into four group: normal group, model group, positive control group and different COS treatment group. Blood sample was taken out from rats at the end of the experiments after 24 hours’ fasting for determination of the blood glucose, fructosamine. Fresh liver was taken out for determination of the glycogen, SOD, MDA. Results: Comparing with the normal group, the blood glucose, fructosamine were obviously different in model group (p<0.01). The above mentioned index was improved (p<0.05) at the end of the experiments in COS group. And the effect was determined by dosage and molecular. Conclusions: The best molecular of COS was 1700, and the dosage was 140 mg/kg·d in this diabetic model.

Key words: chitooligosaccharides, diabetes mellitus, glycogen, SOD, MDA