Abstract: Objective: The effects of soybean isoflavone(SIF) on antioxidative ability in diabetic rats were studied in this assay. Methods: Twenty-six healthy male rats were assigned to three groups:normal control group(N), diabetic control group(DC), and soybean is olflavone-treated group(SI). 100 mg/kg·d islflavone was given to SI group by gavage. After 6 weeks, T-AOC, SOD, GSH-Px, XOD and MDA in serum and liver were tested. Results: Fasting blood glucose level in SI group was significantly lower before given than those in DC group (p<0.05). The fasting blood glucose level in DC group was remarkably higher than before (p<0.05). Comparing with DC group, GSH-Px and SOD activities of serum and liver in SI group were higher remarkably (p< 0.05);T-AOC level in liver was also much higher (p<0.05); MDA level in serum and liver in SI group were much lower than thosein DC group(p<0.05); although XOD level of serum and liver in SI group were lower than DC group. Conclusion: SIF has the ability of decreasing blood glucose level and improving antioxidant ability. The studies showed that recovering of βcell damage via the way of inhibitingβcell of pancreas islet and insulin receptors of liver being oxidized continuously might be of the important hyperglycemia lower mechanism of SI.

Key words: soybean isoflavone, diabetic rats, anti-oxidize