FOOD SCIENCE ›› 2007, Vol. 28 ›› Issue (5): 312-316.

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Experimental Study of SPG-1 on Antitumor and Immune Activity of Tumor Mice

 LIU  Zhu, ZHU  Bi-Feng, PENG  Ling, GAO  Jian-Lin   

  1. Yinydong College of Bioengineering,Shaoguan University,Shaoguan 512005,China
  • Online:2007-05-15 Published:2011-12-31

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Abstract: Object:To study the antitumor and immune activity of SPG-1 on H22 tumor mice.Methods:Sweet potato glycoprotein(SPG-1)was extracted from the cultivar Guangdong 98.The kunming H22 fumor mice were given SPG-1 by intragastrical injection(i.g.)then the inhibiting rate of tumor growth,life prolongation rate,katyokinesis index of tumor cells,spleen index,thymus index and the activity on macrophage of celiac plexus were studied.Results:SPG-1 can significantly inhibit the tumor growth(p＜0.05)on H22 entity-tumor mice,significantly prolong life(p＜0.05)on H22 bearing-tumor mice.SPG-1 can obviously inhibit karyokinesis of tumor cells(p＜0.01)on H22 bearing-tumor mice,and notably enhanced the spleen index(p＜0.01),the thymus index(p＜0.05 )and the activity on macrophage of celiac plexus(p＜0.01)on H22 entity-tumor mice. Conclusion:SPG-1 has anti-tumor and immune function on H22 tumor mice.

Key words: sweet potato, glycoprotein, anti-tumor, immunoregulation