Antitumor Effect of Crude Intercellular Polysaccharide of Pholiota squarrosa AS5.245 on Mice with Transplant Heps Tumors in vivo

Abstract

Abstract: Crude intercellular polysaccharide(CIP) was extracted from fermentation mycelium of Pholiota squarrosa AS5.245. The CIP was administered to KM mice with transplant Heps tumors by intraperitoneal injection at different doses,in order to investigate its antitumor effect. The results showed that the CIP could remarkably improve the immunity of Heps mice and inhibit the hepatocarcinoma Heps in mice. Furthermore,this effect is dose-dependent. Compared with control,medium and high dose could significantly increase the thymus and spleen indexes of mice( p < 0.05),while low dose could significantly increase spleen index of mice( p < 0.01). In conclusion,the intercellular polysaccharide of Pholiota squarrosa AS5.245 has antitumor activity and could improve immune function.

Key words: Pholiota squarrosa, crude intercellular polysaccharide, antitumor, thymus and spleen index, immune function

ZHAO Hai-Zhen, WANG Juan, 吕Feng-Xia , BIE Xiao-Mei, LU Zhao-Xin. Antitumor Effect of Crude Intercellular Polysaccharide of Pholiota squarrosa AS5.245 on Mice with Transplant Heps Tumors in vivo[J]. FOOD SCIENCE, 2008, 29(12): 678-680.

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Antitumor Effect of Crude Intercellular Polysaccharide of Pholiota squarrosa AS5.245 on Mice with Transplant Heps Tumors in vivo

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