FOOD SCIENCE ›› 2008, Vol. 29 ›› Issue (6): 399-403.

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Study on Antihypertensive Activity of Peanut Oligopeptide

 ZHANG  Yu-Hao, MA  Liang, WANG  Qiang   

  1. 1.College of Food Science, Southwest University, Chongqing 400715, China; 2. Institute of Processing for Agricultural Products, Chinese Academy of Agricultural Sciences, Beijing 100094, China
  • Online:2008-06-15 Published:2011-08-26

Abstract: ACE inhibitory activity of peanut oligopeptide was evaluated by chemical models in vitro. The results showed that ACE inhibitory activity of peanut oligopeptide below 1 kD is outstanding, and its IC50 value is 0.255 mg/ml. Peanut oligopeptides below 1 kD are found to belong to competitive innibitor to ACE and they can resist hydrolysis of digestive enzyme by mechanism research. The SBP of SHRs is reduced markedly by peanut oligopeptides below 1 kD and the heart rate of SHRs is not influenced. Peanut oligopeptides below 1 kD could steadily reduce SBP of SHRs and could be absorbed completely into blood circulation.

Key words: peanut oligopeptides, ACE, antihypertensive activity