Abstract:

The dried mycelia of Diasporangium sp. recombinant strain D-A1 which was a hybrid of Aspergillus niger and Diasporangium sp. obtained by genome shuffling was analyzed for their general nutritional ingredient and their regulation effect on blood lipids and prevention effect on atherosclerosis in mice were studied. The dried mycelia of the recombinant strain D-A1 contained 15.21% protein and 30.34% lipid of which arachidonic acid accounted for 16.75%. Obvious preventions in ascension of total cholesterol (TC) and triglyceride (TG) were found in high-fat model mice fed 1.2 g/kg of the dried mycelia of the recombinant strain D-A1 for 35 days. The low-density lipoprotein cholesterol (LDL-C) level of mycelia powder-fed group was reduced by 70.94% when compared with that of the high-fat diet model group, while the high-density lipoprotein cholesterol (HDL-C) level was found to be enhanced by 42.58%. The mycelia powder of Diasporangium sp. recombinant strain D-A1 has a high nutritional value, which can prevent hyperlipemia effectively, and exhibits remarkable regulation actions to the blood lipid metabolism disorder of mice.

Key words: Diasporangium sp., nutritional ingredient, arachidonic acid, cholesterol, blood lipid