Antioxidant and Hypoglycemic Activities of Phloridzin-6"-O-salicylate

doi:10.7506/spkx1002-6630-200919065

Abstract

Abstract:

Objective: To evaluate bioactivity of the new compound, phloridzin-6"-O-salicylate. Methods: Diabetic mice were orally administered with phloridzin-6"-O-salicylate and methformin was used as a positive control. Fasting and non-fasting blood glucose levels, glucose tolerance, and 2,2’-diphenyl-1-picrylhydrazyl free radical (DPPH·) scavenging capability were detected. Results: IC50 of phloridzin-6"-O-salicylate for DPPH· scavenging was 113 mg/L, which was significantly lower than that of phloridzin (IC50 = 163 mg/L). Moreover, phloridzin-6"-O-salicylate had better effects on the control of fasting and nonfasting blood glucose levels and glucose tolerance in diabetic mice than phloridzin. Conclusion: Hypoglycemic and antioxidant activities of phloridzin modified by salicylate esterification were significantly improved.

Key words: phloridzin-6"-O-salicylate, diabetes, hypoglycemia, antioxidation, DPPH free radical

CLC Number:

R931.71

DONG Hua-qiang，LI Mei，WU Jian-feng，LIU Fu-lai，MA Ri-an. Antioxidant and Hypoglycemic Activities of Phloridzin-6"-O-salicylate[J]. FOOD SCIENCE, 2009, 30(19): 279-282.

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Antioxidant and Hypoglycemic Activities of Phloridzin-6"-O-salicylate

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