Effects of Liquid Mixture of Monascus and Grape Seed Procyanidins Extract on Levels of Cholesterol and ox-Low Density Lipoprotein of Atherosclerosis Rats

Abstract

Abstract: Objective: To observe the effects of liquid mixture of Monascus and grape seed procyanidins extract (GSPE) on levels of cholesterol and ox-LDL of atherosclerosis rats. Method: The models were developed by administering vitamin D3 and feeding high cholesterol diet. Serial assays of blood cholesterol, triglycerides, HDL-c, LDL-c, ox-LDL of the rats were performed and antioxidant statuses such as SOD, MDA, GSH-Px, and T-AOC were also detected. Results: Compared with those of rats in control group, serum TC, TG, HDL-c, LDL-c and ox-LDL levels of model rats significantly increase. Increases of TC, TG, LDL-c and ox-LDL levels of the rats are inhabited in three experimental group, and the antioxidant statuses are inproved significantly (p< 0.05). But there is no significant difference among HDL-c levels in these groups. Conclusions: The liquid mixture of Monascus and GSPE can delay the progress of the formation and development of atherosclerosis by various pathways.

Key words: Monascus, grape seed procyanidins extract, atherosclerosis, ox-LDL

JIANG Lu, LI Su-Jun, LIU Zong-Lin, HAO Zhao-Lin, HE Ji-Guo. Effects of Liquid Mixture of Monascus and Grape Seed Procyanidins Extract on Levels of Cholesterol and ox-Low Density Lipoprotein of Atherosclerosis Rats[J]. FOOD SCIENCE, 2008, 29(7): 420-423.

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Effects of Liquid Mixture of Monascus and Grape Seed Procyanidins Extract on Levels of Cholesterol and ox-Low Density Lipoprotein of Atherosclerosis Rats

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