Abstract: Purpose: To investigate the effect of oligopeptide from Panax ginseng grown in Jilin province (GOP) on hyperlipidemic rats. Methods: Totally 108 specific pathogen free (SPF) male SD rats were randomly divided into 9 groups: normal control, model, whey protein group, and six GOP groups with different doses. The rats from the normal control group were fed a basal diet only. The rats from the rest groups were fed a high-fat diet for 2 weeks. Then, the rats in six GOP groups were gavaged with GOP at doses of 0.062 5, 0.125 0, 0.250 0, 0.500 0, 1.000 0 and 2.000 0 g/kg, respectively, those in the normal control and model groups with the same volume of distilled water, and those in the whey protein group with whey protein at a dose of 0.250 0 g/kg for 30 days. At the same time, all rats were provided with the corresponding diets uninterruptedly. Results: The TC, LDL-C, HDL-C and TG levels in serum had no significant change in rats from the GOP groups at each dose. The MDA level was significantly decreased and SOD and GSH-Px activities were significantly elevated in serum and liver tissue of rats from the GOP groups. Besides, serum NO and NOS levels were significantly elevated in the GOP groups. Conclusion: GOP does not has a hypolipidemic effect, but it may have an anti-atherosclerosis effect.

Key words: oligopeptide from Panax ginseng grown in Jilin province, SD rats, hypolipidemic, atherosclerosis