Abstract: Antimicrobial effects of leaves extracts of Lonicera japonica Thunb.were investigated. The extracts of Lonicera japonica Thunb. Leaves exhibited variable inhibitory effects against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Salmonella typhimurium, Penicillium notatum, Aspergillus niger, Aspergillus flavus and Saccharomyces cerevisiae which were all harmful to sanitation and safety of food as well as clinical medicine. The minimal inhibitory concentration (MIC) of the flavones from Lonicera japonica Thunb. leaves to each sensitive strain was respectively determined as 125, 62.5, 250, 1000, 250, 62.5, 250 and 250μg/g. The minimal inhibitory concentration (MIC) of the chlorogenic acid from Lonicera japonica Thunb. leaves to each sensitive strain was respectively determined as 250, 250, 500, 2000, 500, 125, 500 and 500 μg/g.

Key words: Lonicera japonica Thunb. leaves, extracts, antimicrobial effect