Abstract: Using the induced diabetic mice, the effects of the silkworm eggs power on the blood glucose, SOD and SOD mRNA expression in diabetic mice were studied. The results showed that the blood glucose decreased dramatically in diabetic mice after fed on diet containing 5% silkworm eggs power for 45 days, but no effect in normal mice. The superoxide dismutase (SOD) in the liver of diabetic mice was lower compared to the normal mice. When fed on 5% silkworm eggs power, the activity of superoxide dismutase increased again, almost reach to the normal level. The results both RT-PCR and Northern Blotting demonstrated that the mRNA of superoxide dismutase gene in diabetic mice develop to the normal level after fed on diet containing 5% silkworm eggs power for 45 days. The results construct the basis for further experiments of the function and amplification of silkworm eggs power.

Key words: silkworm eggs power, blood glucose, superoxide dismutase, mRNA