Abstract: Objective To study the anti-fatigue effect of Acanthopanax senticosus extract. Methods The male mice of BALB/ c were randomly divided into four groups according to their body weight: a solvent control group , Acanthopanax senticosus extract 200, 400 and 700mg/kgbw group. The mice were administered respectively with water and 200 , 400, 700mg/kgbw Acanthopanax senticosus extract. After 15 days, the forced swimming test, blood lactic acid and hepatic glycogen content were determined. Results: The swimming time of mice in 700mg/kg.bw group was significantly prolonged as compared with that in control group (p<0.05) . 400mg/kgbw, 700mg/kgbw groups could obviously increased hepatic glycogen storage (p<0.01). 700mg/kg.bw groups could significantly accelerate lactic acid clearance after mice swimming (p<0.01) .Conclusion: Acanthopanax senticosus extract has an anti-fatigue effect.

Key words: Acanthopanax senticosus, anti-fatigue