Abstract: Through administration of lotus seedpod proanthocyanidins (LSPC) at the doses of 20, 50, 100 mg/(kg?d), the effect of LSPC on the protection of organ and tissue injuries in mice with high intensity exercise. The hemoglobin (HB) content, red blood cell (RBC) number and white blood cell (WBC) number were tested for mice after exercise. The biochemical indexes in serum such as glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), blood serum urea nitrogen (BUN), creatinine (Cre), glucose (Glu), lactic acid (LA), lactic dehydrogenase (LDH) and creatine kinase (CK) were also analyzed. The activity of superoxide dismutase (SOD) and the contents of glutathione (GSH) and malondialdehyde (MDA) in muscle and viscera were evaluated, and histological examination was also conducted. The result showed that LSPC can effectively reduce inflammation reaction in the body of mice with high intensity exercise, alleviate oxidative stress-induced injury of tissues and organs, and execute protective function on skeletal muscle and cardiac muscle.

Key words: lotus seedpod proanthocyanidins, mouse, high-intensity exercise, protection against injury