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Effect of D-Ribose on High-Energy Phosphates in Cardiac and Skeletal Muscles of Rats during Swimming and Subsequent Recovery

WANG Yakun1,2, LI Meng2, WEI Zhuan3, SUN Wenjing2,4, LIU Jingze2,*   

  1. 1. Tourism Department, Hebei Normal University, Shijiazhuang 050024, China; 2. College of Life Science, Hebei Normal
    University, Shijiazhuang 050024, China; 3. Department of Pharmaceutical, Hebei Chemical and Pharmaceutical College,
    Shijiazhuang 050026, China; 4. School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
  • Online:2015-06-15 Published:2015-06-07

Abstract:

In order to investigate the effect of D-ribose on the recovery of rat cardiac muscle and skeletal muscle function
during and after loaded swimming, the concentrations of high-energy phosphates such as adenosine triphosphate (ATP),
ATP metabolites and phosphocreatine (PCr) were determined by high performance liquid chromatography (HPLC). Results
showed that the synthesis rate of ATP in skeletal muscle was accelerated significantly by D-ribose; therefore, the same
amount of ATP consumed during swimming was reproduced within 72 h and the energy recovery was accelerated. At
the same time, D-ribose significantly enhanced the concentration of ATP in heart so that the energy supply to heart was
guaranteed and the normal physiological function of heart was maintained during swimming.

Key words: D-ribose, high-energy phosphate materials, high performance liquid chromatography, cardiac muscle, skeletal muscle

CLC Number: