Abstract:

To explore the effect of inulin on immune modulation in mice, 100 BALB/c female mice were allocated to control
group, low-dose inulin group, mid-dose inulin group and high-dose inulin group, respectively. Then, the mice in three inulin
groups were orally administered with inulin at doses of 200, 400 and 600 mg/(kg·d) body weight, respectively. After 15 days
of consecutive administration, immune function indexes in these mice were detected. The results showed that inulin at both
mid and high doses could significantly enhance immune organ indexes, phagocytotic capacity of peritoneal macrophages, the
level of serum hemolysin, lymphocyte proliferation (SI value) and the level of interferon-γ (IFN-γ) (P < 0.05) or (P < 0.01),
indicating that inulin improves immune function in mice to some degree.

Key words: inulin, mice, immune modulation